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Common name Gene symbol Genetic modification Phenotypes Contact
Alpha(1,2)fucosyltransferase Fut1 H gene Fut1 Lac-Z reporter gene knock-in Tentatively normal fertility Steven Domino
Alpha(1,2)fucosyltransferase Fut2 Secretor blood group gene Fut2 Lac-Z reporter gene knock-in Tentatively normal fertility Steven Domino
Delta 6 desaturase D6D transgenic Male hemizygotes have a severe shaking phenotype, a retarded growth pattern, and die by three weeks of age. Female hemizygotes have a slight tremor. Steven D. Clarke
DVr1abD deletion of 16 V1r genes chromosome engineering diminished maternal aggression diminished male-female sexual behavior Peter Mombaerts
GluR-A-/- GRIA1 targeted knock-out decreased motor coordination in rotqa rod increased locomotion Rolf Sprengel
GluR-B deltaECS GRIA2 targeted knock-in dominant negative mutation. Epileptic lethal phenotype between P15 and P25 Rolf Sprengel
hGFAP GFAP transgenic early death in high expressors, low body weight only overt phenotype in surviving lines, distinct histological phenotype of astrocyte hypertrophy and inclusion bodies (Rosenthal fibers) Albee Messing
leaner Cacna1a spontaneous mutation absence seizures cerebellar ataxia Louise Abbott
lethargic Cacnb4 spontaneous mutation Ataxia, absence seizures, episodic dystonia Dan Burgess
Palmitoyl-protein thioesterase-1 PPT1 targeted knock-out mouse model of infantile neuronal ceroid lipofuscinosis (infantile Batten disease) neurological symptoms at 3-5 months, death by 8 months. Homozygotes viable and fertile Sandra Hofmann


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